4 edition of Common mechanisms of transformation by small DNA tumor viruses found in the catalog.
|Statement||edited by Luis P. Villarreal.|
|Series||ICN-UCI conferences in virology|
|Contributions||Villarreal, Luis P., ICN-UCI International Conference on Virology (1989 : Newport Beach, Calif.)|
|LC Classifications||QR372.O58 C66 1989|
|The Physical Object|
|Pagination||x, 259 p. :|
|Number of Pages||259|
|LC Control Number||89017530|
Proviruses are viral DNA integrated into the host cell. Some of the DNA viruses can either initiate an infection (lytic in prokaryotes) cycle or can form proviruses. Simian Virus 40 (SV40) causes cancer in hamsters but not in its normal hosts. SV40 can introduce new functional genes into the host DNA, as can a number of other viruses. -Responsible for transformation & the mechanism of action of the gene products.-Mutant strain of viruses retained the ability to grow in host cells, but unable to transform the cell into malignant properties.-The capacity to transform a cell resided in a restricted portion of the viral genome.-The researchers began by isolating mutant strains of the avian sarcoma virus(ASV).
Papillomaviruses are small DNA viruses that are experts in manipulating the cell cycle of their vertebrate hosts; some can directly cause cancer. Dr. Dan DiMaio is exploring the role of cellular proteins in human papillomavirus (HPV) entry and intracellular trafficking to the nucleus. Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SVcontaminated vaccines.
Some retroviruses (RNA tumor viruses) cause cancer by one of two mechanisms: 1. A virus may contain an additional gene, called an oncogene, which induces the cancerous growth phenotype in the host cell (e.g., Rous sarcoma virus of chickens contains an oncogene called v-src, for viral sarcoma(-causing) gene, Fig. ). cancer-associated viruses and can be identified. The Mouse Mammary Tumor virus (MMTV), in stark contrast to all other 11 viruses displayed significant sequence similarity to the human genome. We identified 28 instances of similarity between MMTV and human genome. Four unique segments of MMTV DNA are incorporated at 28 locations in the human genome.
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: Common Mechanism Transformtn Small Dna Tumor Viruses (): Villarreal: Books. The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p Levine AJ(1). Author information: (1)Institute for Advanced Study, Princeton, NJUSA.
[email protected] The small DNA tumor viruses, Polyoma virus, Simian Vacuolating Vi Cited by: Rb, like p53, is a tumor suppressor gene regulating the entry of cells into the cell cycle, and the inactivation of the Rb protein by the oncogenes of the small DNA tumor viruses makes these viruses tumor viruses.
The transforming ability of these viruses is simply a by product of their need to initiate DNA replication in the cells they choose to replicate by: Get this from a library. Common mechanisms of transformation by small DNA tumor viruses. [Luis P Villarreal;].
Small DNA tumor viruses are a fascinating group of double-stranded DNA viruses, made up of the polyomavirus, the adenovirus, and the papillomavirus families.
These viruses continue to provide fundamental insights into mammalian cell transformation, cell cycle control, and tumor formation. This review compares and contrasts the approaches DNA tumor viruses have evolved to antagonize Rb family members—ranging from relatively simple equilibrium dissociation of pRb from cellular pRb-binding factors to chaperone-mediated alterations in pocket protein stability and phosphorylation by: Members of the sixth family of tumor viruses, the retroviruses, have RNA genomes in virus particles but replicate via synthesis of a DNA provirus in infected cells.
The viruses that cause human cancer include hepatitis B virus (liver cancer), papillomaviruses (cervical and other anogenital cancers), Epstein-Barr virus (Burkitt's lymphoma and nasopharyngeal carcinoma), Kaposi's sarcoma-associated.
Transformation by a virus is the change in the biological properties of a cell that results from the regulation of the cell by viral genes and that confer on the infected cells certain properties of neoplasia. Transformation often includes loss of growth control, anchorage-independent growth.
Non-Transforming Retroviruses: These viruses, unlike the acutely transforming retroviruses, take much longer to develop tumors as they are very slow-acting. Also, unlike acutely transforming retroviruses, they don't disrupt the normal cellular function by the insertion of a viral oncogene.
They take the route of a different mechanism called called insertional mutagenesis. Oncogenic Mechanisms of DNA Tumor Viruses. DNA viruses belonging to the papovavirus, adenovirus, hepadnavirus and herpesvirus families have been associated with tumors in humans and animals [36,37].
Compared to the RNA tumor viruses that activate host genes or use transduced host genes to transform their cell targets, most oncogenic DNA viruses encode their own proteins to induce neoplastic transformation.
Purchase Viruses, Cell Transformation, and Cancer, Volume 5 - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. the viral enzyme, RNA-directed DNA polymerase (reverse transcriptase) into a double-stranded DNA provirus. This provirus, like the genomes of DNA tumor viruses, becomes inserted into host chromosomal DNA, so that the "integrated" viral genes become adopted by the host as extra genetic in.
RNA tumor viruses are different from DNA tumor viruses in that their genome is RNA but they are similar to many DNA tumor viruses in that the genome is integrated into the host genome. Since RNA makes up the genome of the mature virus particle, it must be copied to DNA prior to integration into the host cell chromosome.
Key Takeaways Key Points. Both DNA and RNA viruses have been shown to be capable of causing cancer in humans. Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA viruses that are capable of causing the development of human cancers.
Human papilloma virus (HPV), a DNA virus, causes transformation in cells through interfering with tumor suppressor proteins such as p Interfering with the action of p53 allows a cell infected with the virus to move into a different stage of the cell cycle, enabling the virus genome to be replicated.
The remarkable capacity of some viruses to adapt to new hosts and environments is highly dependent on their ability to generate de novo diversity in a short period of time.
Rates of spontaneous mutation vary amply among viruses. RNA viruses mutate faster than DNA viruses, single-stranded viruses mutate faster than double-strand virus, and genome size appears to correlate Cited by: Excerpt At the time of the last Cold Spring Harbor Laboratory Symposium on tumor viruses ininterest centered on what seemed to be the central element in transformation by DNA viruses: tumor Author: Hung Fan.
Cancer is a collective name for many different diseases caused by a common mechanism: uncontrolled cell division. Despite the redundancy and overlapping levels of cell-cycle control, errors occur. One of the critical processes monitored by the cell-cycle checkpoint surveillance mechanism is the proper replication of DNA during the S phase.
Start studying Cell transformation by Viruses. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
DNA Tumor viruses transform cells by -It is the 3rd most common cancer caused by virus infecton, In Africa due to AIDS epidemic, KS is the most common cancer.
carcinoma; and human papillomavirus with cervical cancer and anogenital carcinoma. Mechanisms of oncogenesis can include transformation (Epstein-Barr virus and herpesvirus 8) and binding of tumor suppressor proteins (human papillomavirus), among others. Diagnosis of Viral Infections Size: 68KB.
herpesviruses. Because of their relatively small genomes and striking biological e ects, it is generally assumed that DNA tumor viruses have evolved to target the minimal number of cellular nodes and pathways required for transformation. Studies of DNA viruses have led to the identi cation of viral genes responsible for cancer induction and.
This article is the second of a 2-part series on cancer virology. An introduction to the infectious causes of cancer can be found here. Human tumor viruses account for an estimated 12% to 20% of cancers worldwide.
Viruses can lead to cancer by associating with host proteins, proliferating when the human immune system is weakened, and hijacking proliferating human cells.
They act with different mechanisms depending on different factors. The tumor viruses with small genomes integrate into host cell chromosomal DNA and cause mutations and chromosomal rearrangements that predispose to cancer.
The oncogenic DNA and RNA viruses that are carrying oncogenes encode transforming proteins to stimulate tumor formation.